Search results for "Immune complex formation"

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The quantitative humoral immune response to the hepatitis C virus is correlated with disease activity and response to interferon-alpha.

1996

Virus-host interactions may have pathogenetic significance in chronic hepatitis. Thus the humoral immune response was evaluated during the clinical course of HCV-infected patients.Eighteen selected chronic HCV patients received three doses of 3 or 6 MU interferon-alpha 2a weekly for 6 to 12 months and were followed up for 6 to 60 months. Anti-HCV antibody levels were serially measured either in end-point diluted sera with the Matrix-Assay or with quantitative anti-HC34-IgG and -IgM ELISA. Circulating immune complexes were assessed by flow cytometry and the results were correlated with histology, quantitative HCV-RNA levels and genotypes.Nine complete responders (CR; genotypes 1a n = 4; 1b n…

AdultMaleGenotypeHepatitis C virusAlpha interferonEnzyme-Linked Immunosorbent AssayAntigen-Antibody ComplexHepacivirusBiologyInterferon alpha-2Immune complex formationmedicine.disease_causeVirusImmune systemInterferonmedicineHumansHepatologyInterferon-alphaHepatitis CHepatitis C AntibodiesMiddle Agedmedicine.diseaseFlow CytometryHepatitis CRecombinant ProteinsImmunologyAntibody Formationbiology.proteinFeasibility StudiesRNA ViralFemaleAntibodymedicine.drugJournal of hepatology

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